CellRestorix Labs
PNC-27
Strictly intended for in vitro laboratory research and scientific evaluation. Not for human or animal use.
≥99% HPLC Purity

Independent lab tested

Sterile Lyophilized

Vacuum sealed flip-off vial

RESEARCH USE ONLY (RUO)

PNC-27

In Stock · Batch Verified SKU: CRX-039
$85.00
per research vial
Institutional Tiered Pricing
1–2: Base price 3–5: 10% OFF 6+: 15% OFF

Research Focus: PNC-27 is an engineered synthetic peptide containing the p53 HDM-2 binding domain (residues 12-26) linked to a membrane-penetrating sequence, investigated in cancer cell membrane lysis models.

Chemical / Molecular Info: Class: Synthetic p53-derived membrane-active peptide.

Research Use Only (RUO) Notice

For Research Use Only (RUO). This product is strictly intended for in vitro laboratory research and scientific evaluation. It is not intended for human or veterinary use, consumption, diagnosis, treatment, cure, or prevention of any disease.

Description

Research Product Overview

PNC-27 is an engineered synthetic peptide containing the p53 HDM-2 binding domain (residues 12-26) linked to a membrane-penetrating sequence, investigated in cancer cell membrane lysis models.

Scientific Research Applications

  • p53-HDM2 interaction modeling
  • Tumor cell membrane-specific pore formation
  • Membrane integrity and cellular lysis kinetics
  • In vitro oncology models
  • Targeted peptide cytotoxicity mechanisms

Analytical Specifications & Purity

Purity: ≥99% (Verified via HPLC / LC-MS)

Documentation: Certificate of Analysis (COA) & batch traceability included.

Chemical Info: Class: Synthetic p53-derived membrane-active peptide.

Laboratory Storage & Handling

  • Store lyophilized powder at -20°C in a dry environment protected from light.
  • Once reconstituted, store between 2–8°C and use promptly.
  • Maintain strict aseptic laboratory handling practices.
⚠️ RESEARCH USE ONLY (RUO)

This compound is supplied strictly for in vitro laboratory research and scientific evaluation by qualified personnel. Not for human, veterinary, diagnostic, or therapeutic use.

COA Preview
✓ HPLC & LC-MS VERIFIED LOT

Batch Quality Control & HPLC Certification

Every batch of PNC-27 undergoes High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) in independent U.S. testing facilities, ensuring verified purity ≥99.0%.

BATCH ID: CRX-039-USA · CONFIRMED PURITY: ≥99.2% HPLC
View Central COA Library →

Standard Reconstitution Protocol

🛡️ Laboratory Preparation

Before beginning, allow both the lyophilized peptide and the recommended solvent to reach room temperature.

Prepare a clean laboratory work surface and wear appropriate personal protective equipment, including laboratory gloves and eye protection. Before handling the vials, carefully sanitize the rubber stoppers of both the peptide and solvent with an alcohol wipe.

💧 Recommended Solvent

Always use the solvent specified in each peptide's analytical monograph. Depending on compound characteristics, reconstitution may require sterile Bacteriostatic Water or an Acetic Acid solution.

Before proceeding, consult compound-specific technical documentation to determine the appropriate solvent. Different reconstitution solvents must not be considered interchangeable between peptides.

🧪 Reconstitution Procedure
  • Using a sterile laboratory syringe, draw the required volume of the recommended solvent.
  • Incline the vial at approximately 45° and slowly introduce the solvent along the inner glass wall, avoiding direct pressurized contact onto the lyophilized cake.
  • Do not shake the vial vigorously. Allow contents to dissolve gently to minimize foaming and preserve sample molecular integrity.
  • Once reconstituted, the solution should present the appearance specified for each individual product. Where applicable, it must appear clear and free of visible particulate matter.

Storage & Stability Guidelines

❄️ Prior to Reconstitution — Lyophilized Peptide
  • Short-term storage:
    Keep product refrigerated between 2 °C and 8 °C.
  • Long-term storage:
    Maintain at −20 °C or lower, protected from light, moisture, and frequent temperature fluctuations.
🧪 Post-Reconstitution

Once reconstituted, store product refrigerated between 2 °C and 8 °C, unless compound-specific parameters dictate alternative conditions.

Avoid unnecessary temperature variations and repeated freeze-thaw cycles.

Storage conditions may vary depending on the peptide and solvent utilized. Product-specific monographs, technical documentation, and stability data must always take precedence.

📋 Scope of this Guideline
Does this guide provide dosage, administration, or usage instructions?

No. Information regarding reconstitution and storage is provided strictly as reference material for scientific research activities.

This guide does not establish or recommend dosages, routes of administration, treatment protocols, or instructions for human or veterinary use.

The information presented outlines general laboratory handling practices for research materials and does not substitute for the specific standard operating procedures, protocols, controls, or safety requirements established by each individual research facility. Where applicable, specific product monographs and associated analytical documentation must be strictly observed.

RESEARCH USE ONLY (RUO) NOTICE

For Research Use Only (RUO). This product is strictly intended for in vitro laboratory research and scientific evaluation. It is not intended for human or veterinary use, consumption, diagnosis, treatment, cure, or prevention of any disease.

RESEARCH USE ONLY (RUO) — Regulatory Compliance

FOR RESEARCH USE ONLY (RUO). All products are strictly intended for laboratory in vitro research and scientific evaluation. Not intended for human or veterinary use, consumption, diagnosis, treatment, cure, or prevention of any disease.

• Not for Consumption: Compounds and reagents distributed by CellRestorix Labs are synthesized strictly for in vitro scientific evaluation and professional laboratory use.
• No Clinical Approval: These products are NOT pharmaceuticals, dietary supplements, or veterinary therapeutics, and are not approved by the FDA or international health agencies for disease treatment, diagnosis, or human application.
• Strict Compliance Policy: Any indication of improper handling, unauthorized clinical usage, or personal administration will result in immediate termination of supply and permanent account revocation.

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